Double opportunistic- double negative: histoplasmosis coinfection and Mycobacterium infection, in an immune-competent patient

Authors

DOI:

https://doi.org/10.47464/MetroCiencia/vol30/2/2022/71-79

Keywords:

Histoplasmosis, tuberculosis pulmonar, coinfection, respiratory failure

Abstract

Opportunistic infections such as tuberculosis (TB) and serious bacterial, fungal, and parasitic infections are the most common causes of death among adults with advanced HIV disease.[1] The coinfection of both microorganisms has been documented in patients living with the Human Immunodeficiency Virus (HIV), in the AIDS phase[2]. There are very few data about coinfection in patients who are not immunocompromised. We present a clinical case of a young adult patient who presented with frank respiratory insufficiency, had previously been diagnosed with mycobacterial infection, upon reassessment of the patient it was decided to study hepatosplenomegaly due to pancytopenia, with liver biopsy showing Disseminated Histoplasmosis. treatment according to guidelines with Amphotericin B, and anti-phimic management with quadruple therapy. With evident clinical improvement, the patient has almost completely recovered his lung and kidney function and his homeostasis in general.

Downloads

Download data is not yet available.

Author Biographies

  • Juan José Romero , Hospital Metropolitano

    Médico Internista-Infectólogo. Tratante de Infectología. Hospital Metropolitano, Quito, Ecuador

  • José Xavier López Rosas, Hospital Metropolitano

    Médico Posgradista de Medicina Interna. Hospital Metropolitano, Quito, Ecuador

References

Pérez F, Cáceres DH, Ford N, Ravasi G, Gómez BL, Pasqualotto AC, et al. Summary of guidelines for managing histoplasmosis among people living with HIV. Journal of Fungi 2021;7:1–8. https://doi.org/10.3390/jof7020134.

Diagnosis and treatment of disseminated histoplasmosis in HIV-uninfected patients - UpToDate n.d.

Anot K, Sharma S, Gupta M, Kaur D. Disseminated histoplasmosis and tuberculosis: dual infection in a non-endemic region. BMJ Case Reports 2020;13. https://doi.org/10.1136/bcr-2020-235531.

Evrard S, Caprasse P, Gavage P, Vasbien M, Radermacher J, Hayette MP, et al. Disseminated histoplasmosis: case report and review of the literature. Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine 2018;73:356–63. https://doi.org/10.1080/17843286.2017.1376454.

Muñoz-Oca JE, Villarreal Morales ML, Nieves-Rodríguez A, Martínez-Bonilla L. Concomitant disseminated histoplasmosis and disseminated tuberculosis after tumor necrosis factor inhibitor treatment: A case report. BMC Infectious Diseases 2017;17. https://doi.org/10.1186/s12879-016-2097-7.

de D, Nath UK. Disseminated Histoplasmosis in Immunocompetent Individuals- not a so Rare Entity, in India. Mediterranean Journal of Hematology and Infectious Diseases 2015;7. https://doi.org/10.4084/MJHID.2015.028.

Samaddar A, Sharma A, Kumar PH A, Srivastava S, Shrimali T, Gopalakrishnan M, et al. Disseminated histoplasmosis in immunocompetent patients from an arid zone in Western India: A case series. Medical Mycology Case Reports 2019;25:49–52. https://doi.org/10.1016/j.mmcr.2019.07.012.

Cáceres DH, Valdés A. Histoplasmosis and tuberculosis co-occurrence in people with advanced HIV. Journal of Fungi 2019;5. https://doi.org/10.3390/jof5030073.

Ling Q, Zhu W, Lu Q, Jin T, Ding S. Disseminated histoplasmosis in an immunocompetent patient from an endemic area: A case report. Medicine (United States) 2018;97. https://doi.org/10.1097/MD.0000000000011486.

Falci DiR, Monteiro AA, Braz Caurio CF, Magalhães TCO, Xavier MO, Basso RP, et al. Histoplasmosis, An Underdiagnosed Disease Affecting People Living with HIV/AIDS in Brazil: Results of a Multicenter Prospective Cohort Study Using Both Classical Mycology Tests and Histoplasma Urine Antigen Detection. Open Forum Infectious Diseases 2019;6. https://doi.org/10.1093/ofid/ofz073.

Published

2022-06-30

Issue

Section

Casos Clínicos

How to Cite

Double opportunistic- double negative: histoplasmosis coinfection and Mycobacterium infection, in an immune-competent patient. (2022). Metro Ciencia, 30(2), 71-79. https://doi.org/10.47464/MetroCiencia/vol30/2/2022/71-79

Similar Articles

11-20 of 107

You may also start an advanced similarity search for this article.