MIS-C and COVID-19: clinical and epidemiological characteristics in a pediatric critical care unit

Authors

DOI:

https://doi.org/10.47464/MetroCiencia/vol29/3/2021/5-10

Keywords:

COVID-19, Pediatrics, MIS-C, SARS-CoV-2, Coronavirus, Viral Pneumonia

Abstract

The Coronavirus Disease (COVID-19) at the pediatric age, usually have an asymptomatic course or mild symptoms. Nevertheless, a serious disease, with a great inflammatory pattern has been reported and called MIS-C (Multisystemic Inflammatory Syndrome in Children). Material and methods: We conducted a descriptive study of patients from 1 month to 14 years with diagnostic confirmation of COVID-19 admitted to the differentiated pediatric critical care Unit (PICU) at “Hospital Edgardo Rebagliati Martins”. We reviewed medical records and created a follow-up system with a structured questionnaire for recording information. Results: We evaluated 26 children with COVID-19, the median age was 8,4 years and 53% were male. 42% of our population presented some kind of comorbidity. The most frequent symptoms and signs reported were fever (73%), vomiting and nausea (50%), general malaise (50%), abdominal pain (46%), and strains (50%). 68% presented lymphopenia and 85% had an abnormal image on chest radiograph. The median length of stay in the PICU was 6 days. 35% had a severe disease with COVID-19 as intercurrence, 58% met the criteria of MIS-C and 8% had a suspected SARS-CoV-2 pneumonia, 15.38% of the children died. Conclusion: It is extremely important to know the clinical spectrum of how COVID-19 develops in the pediatric population. MIC-S presented as a refractory shock condition, so it should be suspected in this entity if it presents with this clinical pattern.

Downloads

Download data is not yet available.

Author Biographies

  • Manuel Eduardo Munaico Abanto, Hospital Nacional Edgardo Rebagliati Martins

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

  • Perlita Paredes Zevallos, Hospital Nacional Edgardo Rebagliati Martins

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

  • Gaudi Amelia Quispe Flores

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

  • Liza María Manchego Rosado, Hospital Nacional Edgardo Rebagliati Martins

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

  • Ángel Ricardo Galarza Robles, Hospital Nacional Edgardo Rebagliati Martins

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

  • Viviana Palma Monserrate, Hospital Nacional Edgardo Rebagliati Martins

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

  • Manuel Ortiz Chicchon, Hospital Nacional Edgardo Rebagliati Martins

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

  • Guillermo Javier Quiñones García, Hospital Nacional Edgardo Rebagliati Martins

    Médico-Asistente del Servicio de Cuidados Intensivos Pediátricos del Hospital Nacional Edgardo Rebagliati Martins. Lima-Perú

References

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. el 15 de febrero de 2020;395(10223):507–13.

CDC. COVID-19 Response Team. Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020. MMWR Morb Mortal Wkly Rep. el 10 de abril de 2020;69(14):422–6.

Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6).

She J, Liu L, Liu W. COVID-19 epidemic: Disease characteristics in children. J Med Virol. 2020;92(7):747–54.

Pathak EB, Salemi JL, Sobers N, Menard J, Hambleton IR. COVID-19 in Children in the United States: Intensive Care Admissions, Estimated Total Infected, and Projected Numbers of Severe Pediatric Cases in 2020. J Public Health Manag Pract JPHMP. agosto de 2020;26(4):325–33.

MINSA. Covid 19 en el Perú - Ministerio de Salud [Internet]. Sala situacional de COVID-19. Perú. 2020 [citado el 27 de julio de 2020]. Disponible en: https://covid19.minsa.gob.pe/sala_situacional.asp

Llaque-Quiroz P, Prudencio-Gamio R, Echevarría-Lo4pez S, Ccorahua-Paz M, Ugas-Charcape C. Características clínicas y epidemiológicas de niños con COVID-19 en un hospital pediátrico del Perú. Rev Peru Med Exp Salud Pública [Internet]. el 6 de noviembre de 2020 [citado el 26 de noviembre de 2020];37(4). Disponible en: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/6198

Bustos B R, Jaramillo-Bustamante JC, Vasquez-Hoyos P, Cruces P, Díaz F. Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2: A Case Series Quantitative Systematic Review. Pediatr Emerg Care. el 10 de noviembre de 2020;

Ahmed M, Advani S, Moreira A, Zoretic S, Martinez J, Chorath K, et al. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine [Internet]. el 1 de septiembre de 2020 [citado el 26 de noviembre de 2020];26. Disponible en: https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30271-6/abstract

Coll-Vela LED, Zamudio-Aquise MK, Nuñez-Paucar H, Bernal-Mancilla RR, Schult-Montoya SC, Paz MC-DL, et al. Síndrome inflamatorio multisistémico asociado a COVID-19 en niños: serie de casos en un hospital pediátrico de Perú. Rev Peru Med Exp Salud Pública. el 13 de noviembre de 2020;37(3):559–65.

Dhochak N, Singhal T, Kabra SK, Lodha R. Pathophysiology of COVID-19: Why Children Fare Better than Adults? Indian J Pediatr. 2020;87(7):537–46.

Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. el 24 de febrero de 2020;

Escobar G, Matta J, Taype-Huamaní W, Ayala R, Amado J. Características clínicoepidemiológicas de pacientes fallecidos por COVID-19 en un hospital nacional de Lima, Perú. Rev Fac Med Humana. el 11 de abril de 2020;20(2):1–1.

Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Carducci FIC, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health [Internet]. el 25 de junio de 2020 [citado el 27 de julio de 2020];0(0). Disponible en: https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(20)30177-2/abstract

Cui X, Zhao Z, Zhang T, Guo W, Guo W, Zheng J, et al. A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19). J Med Virol. febrero de 2021;93(2):1057–69.

Chao JY, Derespina KR, Herold BC, Goldman DL, Aldrich M, Weingarten J, et al. Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 at a Tertiary Care Medical Center in New York City. J Pediatr. agosto de 2020;223:14-19.e2.

Kaushik S, Aydin SI, Derespina KR, Bansal PB, Kowalsky S, Trachtman R, et al. Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City. J Pediatr. septiembre de 2020;224:24–9.

Blumfield E, Levin TL. COVID-19 in pediatric patients: a case series from the Bronx, NY. Pediatr Radiol. septiembre de 2020;50(10):1369–74.

Dadashi M, Khaleghnejad S, Abedi Elkhichi P, Goudarzi M, Goudarzi H, Taghavi A, et al. COVID-19 and Influenza Co-infection: A Systematic Review and Meta-Analysis. Front Med. el 25 de junio de 2021;8:681469.

Zhu X, Ge Y, Wu T, Zhao K, Chen Y, Wu B, et al. Co-infection with respiratory pathogens among COVID-2019 cases. Virus Res. agosto de 2020;285:198005.

Yasuhara J, Kuno T, Takagi H, Sumitomo N. Clinical characteristics of COVID-19 in children: A systematic review. Pediatr Pulmonol. octubre de 2020;55(10):2565–75.

Mantovani A, Rinaldi E, Zusi C, Beatrice G, Saccomani MD, Dalbeni A. Coronavirus disease 2019 (COVID-19) in children and/or adolescents: a meta-analysis. Pediatr Res. marzo de 2021;89(4):733–7.

Bhuiyan MU, Stiboy E, Hassan MZ, Chan M, Islam MS, Haider N, et al. Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis. Vaccine. el 22 de enero de 2021;39(4):667–77.

Hoang A, Chorath K, Moreira A, Evans M, Burmeister-Morton F, Burmeister F, et al. COVID-19 in 7780 pediatric patients: A systematic review. EClinicalMedicine [Internet]. el 26 de junio de 2020 [citado el 27 de julio de 2020];0(0). Disponible en: https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30177-2/abstract

Pouletty M, Borocco C, Ouldali N, Caseris M, Basmaci R, Lachaume N, et al. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort. Ann Rheum Dis. 2020;79(8):999–1006.

Rauf A, Vijayan A, John ST, Krishnan R, Latheef A. Multisystem Inflammatory Syndrome with Features of Atypical Kawasaki Disease during COVID-19 Pandemic. Indian J Pediatr. el 28 de mayo de 2020;

Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ [Internet]. el 3 de junio de 2020 [citado el 25 de julio de 2020];369. Disponible en: https://www.bmj.com/content/369/bmj.m2094

Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2. Arthritis Rheumatol Hoboken NJ. abril de 2021;73(4):e13–29.

Greene AG, Saleh M, Roseman E, Sinert R. Toxic shock-like syndrome and COVID-19: Multisystem inflammatory syndrome in children (MIS-C). Am J Emerg Med. noviembre de 2020;38(11):2492.e5-2492.e6.

Al Lawati Z, Al Rawahi H, Al Yazidi LS. Acute appendicitis mimicking multisystem inflammatory syndrome in children: case report and review of the literaturE. J Paediatr Child Health. marzo de 2021;57(3):461–2.

McArdle AJ, Vito O, Patel H, Seaby EG, Shah P, Wilson C, et al. Treatment of Multisystem Inflammatory Syndrome in Children. N Engl J Med. el 1 de julio de 2021;385(1):11–22.

Son MBF, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, et al. Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. N Engl J Med. el 1 de julio de 2021;385(1):23–34.

Published

2021-10-05

Issue

Section

Artículo original (Medicina y Cirugía)

How to Cite

MIS-C and COVID-19: clinical and epidemiological characteristics in a pediatric critical care unit. (2021). Metro Ciencia, 29(3), 5-10. https://doi.org/10.47464/MetroCiencia/vol29/3/2021/5-10

Similar Articles

1-10 of 427

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)